Haematobiochemical alterations of induced ethylene glycol toxicity and its amelioration by Tribulus terestris in rats Nakade Mangesh2, Jangde C.R.2, Kamdi Bhupesh1,2,*, Vaidya G.R.2 2Department of Pharmacology and Toxicology, Nagpur Veterinary College, MAFSU, Nagpur, Maharashtra 1PhD Scholar, Division of Veterinary Pathology, Indian Veterinary Research Institute, Izatnagar, U.P. *Corresponding author: e-mail: bhupeshkamdi@gmail.com
Abstract In the present study effect of alcoholic extract of Tribulus terrestris in ethylene glycol induced toxicity in rats was assessed through hemato-biochemical estimation. A total 30 rats were divided into five groups (T4, T2, T3 T4 and T5). Group ‘T4’ served as negative control treated with normal saline. Group ‘T2’ kept as positive control, which received ad-libitum 0.75% ethylene glycol in drinking water for 28 days while group T3 was administered with Hydrochlorthiazide @ 5mg/kg body weight. Alcoholic extract of Tribulus terrestris was prepared and administered @ 50 mg/kg and 100 mg/kg body weight along with ethylene glycol in the test group T4 and T5 respectively. This study was carried out for 28 days wherein hemato-biochemical parameters were recorded at the end of experiment. The mean values of Hb and TLC showed significant differences between T2 (positive control) and treatment groups. While values for TEC and PCV in The T2 (positive control) doesn't show significant difference. Groups treated with Tribulus terrestris extract revealed elevated hematological values as normal group. The mean values of serum calcium, serum alkaline phosphates, serum urea and serum creatinine revealed significant differences between T2 (positive control) and rest of the other treatment groups. However, serum phosphorus showed significance difference (P<0.05). The present study concludes that Tribulus terrestris reduces the toxicity potency of the ethylene glycol. Top Keywords Tribulus terrestris, Ethylene glycol, Hematobiochemical. Top |