A case of concurrent pulmonary and renal cell carcinomas in a German shepherd dog Karikalan M.1,4, Sreelekshmy M.4, Jacob Aron2,4, Sharma D.K.2,4, Mahendran K.2,4, Saxena A.C.3,4, Sharma A.K.4,* 4Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly-243122, Uttar Pradesh, India 1Wildlife Section, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly-243122, Uttar Pradesh, India 2Division of Medicine, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly-243122, Uttar Pradesh, India 3Division of Surgery, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly-243122, Uttar Pradesh, India *Corresponding author: aksharmaivri@rediffmail.com
Abstract A six year old female German shepherd dog was presented to Referral Veterinary Polyclinic of the institute with a history of in appetance and progressive weight loss.The radiography and ultrasonography revealed multiple masses in the lung and single mass on the kidney. The animal died while being treated and a systematic necropsy was done. The right lung showed diffuse tumorous mass involving all the lobes and also diaphragmatic lobe of left lung. The right kidney was markedly enlarged with a very large cystic tumour mass of about 3cm diameter at the anterior pole. Histopathological examination of the lung showed proliferating disorganized neoplastic epithelial cells forming irregular tubulo-papillary structures. The neoplastic cells exhibited large vesicular and hyperchromatic nuclei with prominent nucleolus and frequent mitotic figures. The kidney showed sharp demarcation between normal renal parenchyma and the tumour mass by thick fibrous tissue. The tumour mass was composed of neoplastic cells arranged in solid pattern forming lobular structures separated by inter lobular fibrous connective tissue septae. The neoplastic cells were almost unifom in shape and exhibited round hyperchromatic nuclei with fine dusty chromatin, prominent nucleolus and frequent mitotic figures. Proliferative neoplastic cells were intensely positive for proliferating cell nuclear antigen (PCNA) marker by immunohistochemical staining.The lung tumour cells gave positive staining for pancytokeratin while neoplastic cells of renal tumour gave positive staining for vimentin which showed that both the tumours were of different origin. Top Keywords Adenocarcinoma, Cytokeratin, Dog, Kidney, Lung, Radiography. Top |