Pathomorphological and immunohistochemical characterization of lipid rich mammary carcinoma in a dog Gopal K.*, Srinivasan P., Thangathurai R., Rajeswar J. Johnson, Dharmaceelan S. Department of Veterinary Pathology, Veterinary College and Research Institute, Tirunelveli-627358, Tamil Nadu Veterinary and Animal Sciences University, Chennai - 600051, India *Address for Correspondence, Dr K. Gopal, Department of Veterinary Pathology, Veterinary College and Research Institute, Tirunelveli-627358, Tamil Nadu, India, E-mail: drvetpal@gmail.com
Online Published on 28 July, 2022. Abstract Lipid rich mammary carcinoma is rare in dogs and women. The present study reports a case of lipid rich mammary carcinoma in a seven year old intact female Labrador dog. Clinical examination showed a subcutaneous mass in the left inguinal mammary gland. Fine-needle aspiration cytology of the mass was revealed clusters of malignant neoplastic cells with clear cytoplasmic vacuoles. Histologically, the tumour was multi lobulated and the lobules were separated by fine to moderate fibrovascular stroma. Neoplastic cells had distinct cells borders with moderate to abundant eosinophilic cytoplasm containing numerous small vacuoles or a single large discrete vacuole. Immunohistochemically, the vacuolated cells were negative for hormone receptors (estrogen receptor, progesterone receptor), cytokeratin 5/6 indicating loss of secretory epithelial immunophenotype while vimentin positive in the non-vacuolated stromal cells indicated the mesenchymal cells. Based on gross, histopathological and immunohistochemical features, the case was diagnosed as lipid rich mammary carcinoma in a dog. Top Keywords Cytokeratin 5/6, Dog, Lipid rich mammary carcinoma, Vimentin. Top |