Diagnosis and Immunohistochemical Evaluation of Equine Preputial Tumors Thangapandiyan M.1, Krishnaveni P.1, Kumar V.1,*, Pothiappan P.2, Rao G.V. Sudhakar1 1Department of Veterinary Pathology, Madras Veterinary College, Chennai-600 007, India 2Department of Veterinary Clinical Medicine, Madras Veterinary College, Chennai-600 007, India *Address for Correspondence, Dr V. Kumar, Department of Veterinary Pathology, Veterinary College and Research Institute, Tirunelveli-627 358, Tamil Nadu, India, E-mail: drkumar2000@gmail.com
Online Published on 17 November, 2022. Abstract Two geldings of eight and ten-year-old were presented to the Madras Veterinary College Teaching Hospital with tumor mass on the preputial region. Microscopical examination of one of the preputial mass revealed the presence of loosely arranged fibrovascular stoma with epidermal hyperplasia and hyperkeratosis. Finger like projections, rete pegs extend in to fibromatous tissue were noticed and identified as fibropapilloma. The second mass revealed polyhedral shaped cells with pale blue cytoplasm and keratin pearls, suggestive of squamous cell carcinoma. On immunohistochemical study cytokeratin was expressed in both tumors while vimentin expression was high in squamous cell carcinoma. E-cadherin was poorly expressed in squamous cell carcinoma and intensely positive in Fibropapilloma. Based on histopathology and immunohistochemistry it was classified as poorly differentiated squamous cell carcinoma and prone to metastasis. The current findings concluded a possible role of vimentin in the development and progression of preputial tumour and vimentin and E-cadherin markers will be useful in the diagnosis and prognosis of preputial skin neoplasms in equines. Top Keywords Cytokeratin, e-Cadherin, Fibropapilloma, Squamous cell carcinoma, Vimentin. Top |