Pathomorphological and Immunohistochemical Studies on Malignant Biphasic Mesothelioma in a Non-Descript Dog Gopal K.*, Pazhanivel N., Jeyaraja K., Kumar V., Thangathurai R. Department of Veterinary PathologyVeterinary College and Research Institute, Tirunelveli-627 358, Tamil Nadu Veterinary and Animal Sciences University, Chennai-600 051 *Address for Correspondence, Dr K. Gopal, Assistant Professor, Department of Veterinary PathologyVeterinary College and Research InstituteTirunelveli–627 358, Tamil Nadu, E-mail: drvetpal@gmail.com
Online Published on 17 November, 2022. Abstract A one and half year old male non-descript dog was presented with severe abdominal distension. Clinical examination revealed a hard palpable mass in the abdominal cavity. At necropsy, grey to red firm mass was observed in the mesentery and it was attached with the intestine, pancreas and forms a ball-like structure. Metastases were observed in lung, liver, kidney and mesenteric, renal and mediastinal lymph nodes. Fine needle aspiration cytology revealed single to cluster of round to spindle shaped cells with a moderate amount of basophilic cytoplasm. Histologically, the tumour mass composed of both epithelioid and sarcomatoid cells. Immuohistochemically, the epithelioid cells were positive for cytokeratin and mesenchymal cells were positive for vimentin. Based on the cytology, gross, histopathological and immunohistochemical examination, the case was confirmed as biphasic malignant mesothelioma. Top Keywords Biphasic mesothelioma, Cytokeratin, Dog, Pathology, Vimentin. Top |