Clinico-pathological investigation of inflammatory mammary carcinomas in bitches Nandhini S.1, Madheswaran R.2,*, Balasubramaniam G.A.2, Ramya K.3 1Veterinary Assistant Surgeon, Animal Husbandry Department, Udumalpet, Tiruppur, Tamil Nadu - 642 126 2Department of Veterinary Pathology, Veterinary College and Research Institute, Namakkal - 637 002, Tamil Nadu Veterinary and Animal Sciences University, Tamil Nadu, India 3Department of Veterinary Microbiology, Veterinary College and Research Institute, Namakkal - 637 002, Tamil Nadu Veterinary and Animal Sciences University, Tamil Nadu, India *Address for Correspondence: Dr R. Madheswaran, Department of Veterinary Pathology, Veterinary College and Research Institute (TANUVAS), Namakkal - 637 002, Tamil Nadu, India, E-mail: rmadheswaran2003@gmail.com
Online Published on 03 February, 2023. Abstract A study was conducted to elucidate the altered clinico-pathological parameters in diagnosis and prognosis of inflammatory mammary carcinomas in bitches. Blood and serum samples were collected from 30 each normal and tumor bearing bitches for haemato-biochemical analysis. A significant (P<0.05) reduction of total erythrocyte count and highly significant (P<0.01) reduction of packed cell volume were noticed in tumor affected bitches. A significant (P<0.05) elevation of mean corpuscular haemoglobin and highly significant (P<0.01) elevation of mean corpuscular haemoglobin concentration and total leucocyte count were observed in mammary tumor affected dogs. A significant (P<0.05) increase in total cholesterol and highly significant (P<0.01) increase in alanine transaminase, aspartate transaminase, alkaline phosphatase and potassium values were noticed in tumor bearing bitches. Highly significant (P<0.01) reduction in albumin and significant (P<0.05) reduction in calcium were also noticed. An elevation of superoxide dismutase, reduced glutathione, glutathione peroxidase and lipid peroxidase values whereas reduction of catalase value were noticed in the tumor tissues. Histopathologically, the tumors were classified as benign (2) and malignant (28) tumors with infiltration of inflammatory cells in 18 cases. The haemato-biochemical alterations due to antioxidants and lipid peroxidase were consistent in the diagnosis and management of mammary tumors in bitches. Top Keywords Antioxidants, Biochemistry, Bitches, Haematology, Histopathology, Mammary tumors. Top |