Pathomorphology of gonads in experimental chronic glyphosate toxicity in kuroiler chickens Kalai K.1,*, Behera D.1, Upadhyaya T.N.1, Pathak D.C.1 1Department of Veterinary Pathology, College of Veterinary Science, Assam Agricultural University, Khanapara - 781 022 *Address for Correspondence: Dr Kanika Kalai, Assistant Professor, Department of Veterinary Pathology, College of Veterinary Sciences and A.H., R.K. Nagar, West, Tripura - 799 008, E-mail: kanikakalai@gmail.com
Online Published on 03 February, 2023. Abstract The present study was carried out to study the pathomorphological alterations of gonads as a result of chronic experimental toxicity of glyphosate in kuroiler chickens. Kuroiler birds of 3 months old were divided into 2 groups, Group I and II with 8 birds in each group. Group I was for control and group II for experiment. Group II birds were given glyphosate @ 27.8 mg/kg body weight orally for 90 days. Post mortem examination of gonads revealed that there were no remarkable gross changes in testes but ovaries witnessed a wide range of degenerative changes. Thickening of tunica albugenia and fibrosis of the lining of seminiferous tubules were observed to be one of the notable microscopic lesions in male gonads. Histopathological changes of ovaries revealed degeneration of follicles and oocytes. Besides formation of cyst replacement of normal follicular structure by vacuoles was also observed. The ultrastructural examination of testes revealed disruption of the germ cells, disintegration of nuclear material, dilatation of endoplasmic reticulum, cristeolysis of mitochondria, increased intracytoplasmic vacuolisations and membrane bound vesicles in the cells of germinal tissues. The chronic oral exposure of glyphosate resulted in manifestation of gross, histopathological and ultrastructural alterations of gonads and also found to be a major cause of reduced reproductive performances. Top Keywords Glyphosate, Kuroiler, Ovary, Testes, Ultrastructure. Top |