Versatility of neutrophils in tumor microenvironment Priyanka, Singh Nittin Dev* Department of Veterinary Pathology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Science University, Ludhiana *Address for Correspondence: Dr Nittin Dev Singh, Professor, Department of Veterinary Pathology, COVS, GADVASU, Ludhiana, E-mail: drndsingh@gmail.com
Online Published on 20 June, 2023. Abstract Neutrophils are the most abundant granulocytes in circulation. Its infiltration in cancer has long been documented. However, because of neutrophils short life span and metabolic inefficiency, their contributions have been neglected. In recent years, scientists have realized that neutrophils play a dual function in cancer growth. As tumor progresses, count of neutrophils increases and their phenotype changes. Due to the plasticity of neutrophils, they have diverse population in circulation and cancer. Neutrophils have a variety of roles in the tumor microenvironment and have been labelled as tumor-associated neutrophils (TAN) - pro tumorous and anti tumorous, tumor associated neutrophils (TANs) have identified as key components in the tumor microenvironment. This review discussed neutrophil polarization, diversity, plasticity, previous research on the roles and mechanisms of neutrophils in cancer development, progression, metastasis, and recurrence and also discussed how neutrophils can be targeted as therapeutic approach against cancer. Top Keywords Cancer, Immunosuppression, Myeloid check points, NETs, Plasticity, TANs, Tumor microenvironment. Top |