Histological studies of liver, kidney and reproductive organs and micrometry of infundibulum on carbendazim toxicity and its ame-lioration with vitamin e in female chicken Kiran K. Usha, Kumar A. Anand*, Srilatha Ch.1, Amaravathi P., Sailaja N. Department of Veterinary Pathology, College of Veterinary Science, Sri Venkateswara Veterinary University, Tirupati-517 502, Andhra Pradesh, India 1Professor & University Head, Department of Veterinary Pathology, College of Veterinary Science, Proddatur *Address for Correspondence: Dr A. Anand Kumar, Professor & Head, Department of Veterinary Pathology, College of Veterinary Science, Sri Venkateswara Veterinary University, Tirupati-517 502, Andhra Pradesh, India, E-mail: 7aakumar@gmail.com
Online Published on 20 June, 2023. Abstract Toxico-pathological effect of Carbendazimand its amelioration with vitamin E was assessed infemale chickenby dividing150 day old female chicks into 6 equal groups. The chicks were fedCarbendazim orally from 6th week onwardsat different doses viz; CBZ @ 25 mg/kg BW in T2, T4 and CBZ @ 50 mg/kg BW in T3, T5. Vitamin E @ 25 IU/kg was fed to T6 group. Grossly, liver waspale and fragileatthe end of 10th week and more intensified bythe end of 12th week. Microscopically: congestion, lymphoid aggregates, degenerative changes in the hepatocytes with micro vesicular vacuoles in their cytoplasm of the liver, degenerative changes in the renal tubular epithelium, focal areas of necrosis in the kidney were observed on dose dependent manner. Histologically, ovaries of CBZ treated groups revealed decrease in their yolk content with fat vacuoles, variation in the shape of the follicles, decrease in the number of thecal cells and more atretic follicles and oviduct showed deciliation, de-epithelialization, hyperplastic, atrophied glands with degenerative changes in the CBZ treated groups. In amelioration groups, less severe lesions were noted in comparison to CBZ treated groups. Micrometry analysis of infundibulum supported to distinguish the physiological function of organ or pathological aspect in CBZ toxicity and amelioration groups. The co-administration of vitamin E showed partial amelioration against CBZ toxicity and higher doses may be advocated for its complete amelioration. Top Keywords Amelioration, Carbendazim, Micrometry, Toxicity, Vitamin E. Top |