Polycystic kidney in wistar rats - A case study Mohana N., Krishnaveni P., Yogaraj D., Kavirajan S., Balaje R.M., Murugan S.S., Kumaravel T.S* Department of Toxicology, GLR Laboratories Pvt Ltd, 444 Gokulam Street, Mathur, Chennai-600 068, India *Address for Correspondence T.S. Kumaravel, Department of Toxicology, GLR Laboratories Pvt Ltd, 444 Gokulam Street, Mathur, Chennai-600 068, India, E-mail: kumaravelts@glrlabs.com
Online Published on 2 January, 2024. Abstract The occurrence of polycystic kidney in animals can be attributed to genetic or acquired conditions. In the present study, a morphologically similar case of polycystic kidney disease was detectedin two adult rats. Grossly, numerous variable-sized, spherical-shaped fluid-filled cavities were predominantly observed in the medulla, with no remarkable changes in kidney structure. Polycystic kidney disease (PKD) is a cystic genetic disorder primarily associated with cystic changes in the bile duct and pancreatic duct. There are two forms of PKD: autosomal recessive polycystic kidney disease (ARPKD) and autosomal dominant polycystic kidney disease (ADPKD). ADPKD is the most common form that arises from various segments of the nephron, collecting tubules, and ducts. In ARPKD, the cysts arise from the collecting tubules and ducts. In this manuscript, we report two animals (control animals from two different studies, which received physiological saline and cottonseed oil via intravenous and intraperitoneal routes, respectively) revealed a histopathological pattern consistent with ARPKD, characterized by multiple variable-sized cysts lined by squamous to low cuboidal epithelium predominantly located in the outer medulla, with no degenerative or inflammatory changes. The cystic changes were limited to the kidney without involvement of any other organs. Based on gross and histopathological findings, the present case was diagnosed as spontaneously induced polycystic kidney disease. Top Keywords Autosomal recessive polycystic kidney, Polycystic kidney, Wistar rat. Top |