Correlation of pendrin expression with 131Iodine uptake in post-Nal treated thyroid cancer animal model Gholve C.S., Shete Y.H., Rakshit S., Basu S., Kulkarni S.P.*, Baghel Nawab Singh Radiation Medicine Centre, BARC, C/o TMH Annexe, Parel, Mumbai-400 012, India *Address for Correspondence Kulkarni S.P., Head, TIID, MCF & RP Section, Radiation Medicine Centre, BARC, C/o TMH Annexe, Parel, Mumbai-400 012, E-mail: savitapk@barc.gov.in
Online Published on 27 March, 2024. Abstract Radioactive iodine (RAI) refractoriness develops in the background of a loss of thyroid differentiation features representing major therapeutic challenges in thyroid cancer management. Several studies have reported decreased or even loss of pendrin (SLC26A4 gene) expression in thyroid cancers, signifying the role of pendrin in the impaired ability of thyroid cancer cells for uptake and concentration of iodine. As acute iodide treatment has been shown to increase SLC26A4 mRNA, the study of pendrin expression in malignant tissues is of interest. Hence, we focused on evaluating the pendrin expression and 131I uptake in an N-bis-(2-hydroxypropyl) nitrosamine (DHPN) induced thyroid cancer model in Wistar rats followed by a single dose of excess sodium iodide (NaI) treatment to see if any change occurs in the RAI uptake. 131I uptake by scintigraphy showed thyroid standard uptake values of 10.16±1.6 and 13.13±0.115 in DHPN-treated and control groups respectively at 24 h. However, post-NaI treatment decreasing patterns at 24 h, 48 h and 72 h were observed in a few animals similar to the control. However, the rising pattern of 131I uptake was also observed in a few DHPN-induced thyroid cancer animals compared to the control. In conclusion, further extensive research is warranted to corroborate the role of NaI in the expression of pendrin in conjunction with animal species and age, along with the dose and exposure time of NaI. In addition, the expression and quantification of pendrin at the molecular level could be potentially used to enhance its utility in the management of RAI refractory human thyroid cancer patients. Top Keywords Follicular cells, Immunohistochemistry, 131Iodine uptake, N-bis-(2-hydroxypropyl) nitrosamine, Pathology, Pendrin, Radioactive iodine, Sodium iodide, Thyroid cancer, Wistar rat. Top |