Review on Emerging Drug Delivery Approaches for Treatment of Osteoporosis Kalyani A.1, Srinivasan Bharath2 1Ph. D. Scholar, Department of Pharmaceutics, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Gnanagangothri Campus, New BEL Road, M.S.R. Nagar, Bangalore, Karnataka, India-560054 2Professor and Head, Department of Pharmaceutics, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Gnanagangothri Campus, New BEL Road, M.S.R. Nagar, Bangalore, Karnataka, India-560054 *Corresponding author e-mail: kalyani6009@gmail.com
Online published on 24 January, 2020. Abstract Osteoporosis is a systemic skeletal disease characterized by low bone density and micro architectural deterioration of bone tissue with a consequent increase in bone fragility. This disease can affect anyone, but it is more likely to develop in women, partially due to the increased rate of bone loss at the onset of menopause. Worldwide most of the population suffering from osteoporosis of the hip. The present review provide information on the all the currently and emerging approaches for marketed and researched drug delivery treatment options. Bisphosphonates are the most popular drug therapy in this category. But there are many other treatments that strive to prevent further bone resorption such as hormone therapy, estrogen agonist or antagonists, calcitonin, and denosumab. Other therapies approach the problem of bone loss by inducing the formation of new bone tissue to replace that lost to these pathologies. These include teriparatide, strontium ranelateand statins. These therapies are more effective but it produces the some systemic adverse and side effects. To overcome this problems, development of targeted drug delivery, Nanoparticles and controlled drug delivery through polymer has been investigated. These methods extends the drug half-life, bioavailability and therapeutic efficacy of the osteoporosis treatment. Top Keywords Osteoporosis, Bisphosphonates, Hormone Therapy, Skeletal Disease, Targeted Drug Delivery. Top |