Pleural Mesothelioma in a Labrador Dog Saahithya R.1, Pazhanivel N.2,*, Jeyaraja K.3, Rao Ganne Venkata Sudhakar2 1Assistant Professor, Central University Laboratory, Center for Animal Health Studies, Tamil Nadu Veterinary and Animal Sciences University (TANUVAS), Chennai-600051, Tamil Nadu, India 2Professor, Department of Veterinary Pathology, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University (TANUVAS), Chennai-600007, Tamil Nadu, India 3Department of Veterinary Clinical Medicine, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University (TANUVAS), Chennai-600007, Tamil Nadu, India *Corresponding author email id: drnpvel@gmail.com
Online Published on 02 March, 2024. Abstract Pleural mesotheliomas in dogs are typically infrequent and rare. This report focuses on a nine-year-old male Labrador Retriever dog presenting with a history of dyspnea and reluctance to move. Clinical and ultrasound examinations revealed pleural effusion. The effusion was aspirated via ultrasound-guided thoracocentesis and subjected to further laboratory investigations. Cytological examination of the fluid and cell block technique confirmed the presence of numerous variably sized clusters of neoplastic mesothelial cells. Immunohistochemistry using Mesothelin demonstrated positive expression with a brown color reaction in both the membrane and cytoplasm. Based on the cytology, cell block technique, and positive reactivity to Mesothelin by immunohistochemistry, the case was diagnosed as pleural mesothelioma. Top Keywords Pleural mesothelioma, Cytology, Cell block, Immunohistochemistry, Mesothelin. Top |