Efficacy of lactoferrin in carbon tetrachloride and high fat diet induced hypoglycaemic and hypolipidemic mice Rao Venkata K.V.4,*, Rani Usha M.1, Reddy Gopala A.1, Lakshman M2, Kalyani P3, Swathi B2, Sree Vanitha K1, Rajender B1 1Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Rajendranagar, Hyderabad-520030, Telangana, India 2Department of Veterinary Pathology, College of Veterinary Science, Rajendranagar, Hyderabad-520030, Telangana, India 3Department of Veterinary Biotechnology, College of Veterinary Science, Rajendranagar, Hyderabad-520030, Telangana, India 4Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Garividi-531101, Andhra Pradesh, India *Correspondence author's e-mail: venkata.katuru@gmail.com
Online published on 28 November, 2023. Abstract The present study was conducted to know the ameliorative action of lactoferrin on Hypoglycaemic and Hypolipidemic effects in the Non-alcoholic Fatty Liver Disease (NAFLD) model of male C57BL/6 mice induced by administration of high-fat diet (HFD) + CCl4 (0.5 mg/kg, mixed in olive oil) twice a week via intraperitoneal route for 6 weeks. The results indicated that the levels of cholesterol, triglycerides, LDL, creatinine and BUN were significantly (P<0.05) increased whereas the HDL-cholesterol was significantly decreased in Group 2. In Group 4 lactoferrin @ 300 mg/kg body weight significantly normalized the elevated blood glucose level, body weight and restored the biochemical parameters towards normal level. Treatment with lactoferrin as well as standard simvastatin significantly normalized the altered parameters towards normal. Findings of the present study indicated that lactoferrin possessed both hypoglycemic and hypolipidemic activities. Top Keywords NAFLD, High Fat Diet, Lactoferrin, Glucose and Hyperlipidemia. Top |