The hypoglycemic effect of stem bark of Neolamarckia cadamba on streptozotocin-induced diabetes wistar rats Diwthe Pradnya C.*, Sawarkar A., Somkuwar A.P., Dubey Sonal, Limsay R.P., Umap S. M.V. Sc Student, Department of Veterinary Pharmacology & Toxicology, Nagpur Veterinary College, Nagpur - 440006 *Corresponding author's e-mail: pradnyadiwthe2@gmail.com
Online published on 28 November, 2023. Abstract The present study comprises information on the effects of methanolic extract of stem bark of Neolamarckia cadamba on streptozotocin-induced diabetes in Wistar rats. Group T1, which served as the normal control. Group T2 was a diabetic control and injected with streptozotocin @ a dose of 40mg/kg b. wt. intraperitoneally. Group T3 was treated with metformin @ 100 mg/kg b. wt. Groups T4 and T5 were treated with bark extract of N. cadamba at 300 and 500 mg/kg b wt, respectively. In this study, blood was collected on the 0th, 14th and 28th day for haematological parameters and body weight was measured every week during experiment. Extract of stem bark-treated rats was shown significantly decreases elevated blood glucose levels. Hematological parameters were altered due to streptozotocin-induced diabetes observed towards the normal range after treated with N. cadamba bark extract @ 500 mg/ kg followed by 300 mg/ kg dose rate. In groups (T3, T4, T5), it has been observed that body weight was significantly increased up to the 28th day of treatment as compared to group (T2). The present study concluded that N. cadamba reduces the blood glucose level, improves body weight gain and increases Hb and PCV in the rats. Top Keywords Blood glucose, Diabetes, Haematology, Neolamarckia cadamba, Wistar rats, Streptozotocin. Top |