A Saga of Human Chromosomology: Five Decades of Progress in Human Cytogenetics Sharma Vikas1, Ahuja YR1, Vaidyanath K3,* 1 Research Scholar, Department of Cell and Molecular Biology, Institute of Genetics and Hospital for Genetic Diseases, Hyderabad-500016, Andhra Pradesh, India 2 Director Research, Department of Genetics and Molecular Medicine, Vasavi Medical and Research Centre, Hyderabad-500004, Andhra Pradesh, India 3 Director Research, Department of Genetics and Molecular Medicine, MAA E.N.T Institute, Somajiguda, Begumpet, Hyderabad-500082, Andhra Pradesh, India * Email id: konagurtuv@yahoo.co.in
Abstract Human cytogenetics has a long checkered history of more than five decades. Starting from 1956, when the exact number of chromosome complement in the human genome, as 46 was established irrevocably, it became basic but empowering information in the diagnosis of human genetic disorders and/or syndromes. Since then, the field of human cytogenetics has advanced its scope, not only in understanding the link between chromosomal defects and diseases, but also entered the era of genomics and epigenomics, providing insight into molecular basis of complex diseases and evolution. Various developments in the field of human cytogenetics, from pre-banding era to post-sequencing era are presented in this review. Top Keywords Cytogenetics, Chromosomal defects, Pre-banding era, Genome sequencing. Top |