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Simultaneous Estimation of Metoprolol and Amlodipine from Tablet Dosage Form Chitlange Sohan S.1,*, Md. Imran1, Wankhede Sagar B.1, Sakarkar Dinesh M.2 1Pad. Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411 018 2S. N. Institute of Pharmacy, Pusad, Dist Yawatmol *Corresponding Author E-mail: sohanchitlange@rediffmail.com
Abstract Simple spectrophotometric methods have been developed for simultaneous estimation of Metoprolol (MET) and Amlodipine (AMD) in two component tablet formulation. The methods employed are Absorbance corrected for interference method and Area under curve method. For Absorbance corrected for interference method the working wavelengths selected are 224 nm for MET and 362.5 nm for AMD. Similarly for Area under curve method the working wavelength ranges selected are 234–242 nm (λ1 – λ2) for AMD and 218–228 nm (λ3 – λ4) for MET. For both the methods linearity was observed in the concentration range of 10–50 μg/ml for MET and 4–20 μg/ml for AMD. The recovery studies confirmed the accuracy of proposed method and the methods were validated as per ICH guidelines. Top Keywords Metoprolol, Amlodipine, Absorbance corrected for interference, Area under curve. Top | |
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