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Simultaneous Estimation of Atorvastatin calcium and Nicotinic acid from Tablet Formulation Pillai S.1, Singhvi I.1,*, Kar Mousumi2 1Pacific College of Pharmacy, Air port Road, Pratap Nagar Extension, Udaipur (Raj) 313 001 2Department of Pharmaceutical Sciences, Mohan Lal Sukhadia University, Udaipur (Raj) 313 001 *Corresponding Author E-mail: indrajeetsinghvi@yahoo.com
Abstract Three simple, accurate, economical and reproducible UV spectrophotometric methods for simultaneous estimation of two component drug mixture of atorvastatin calcium and nicotinic acid from combined tablet dosage form have been developed. First developed method involves formation and solving of simultaneous equations using 254.0 nm and 270.0 nm as two wavelengths. Second method is based on two wavelength calculation, wavelengths selected for estimation of atorvastatin calcium were 260.4 nm and 275.6 nm and for nicotinic acid 240.4 nm and 265.2 nm. Third method was developed making use of first order derivative spectroscopy using 233.2 nm and 304.4 nm as zero crossing points for estimation of nicotinic acid and atorvastatin calcium respectively. The results of analysis have been validated statistically and by recovery studies. Top Keywords Spectrophotometric, Atorvastatin calcium, Nicotinic acid. Top | |
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