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Simultaneous Spectrophotometric Methods for Estimation of Metformin and Fenofibrate in synthetic mixture Kothapalli LP*, Mare SG, Thomas AB, Nanda RK, Deshpande AD Department of Pharma. Chem., Pad. Dr. D.Y.Patil Institute Of Pharmaceutical Sciences and Research, Pimpri, Pune-411 018 *Corresponding Author E-mail: lpkothapallidy@yahoo.co.in
Abstract Two simple, rapid, accurate and economical methods have been developed for the estimation of metformin and fenofibrate in synthetic mixture. Metformin has absorbance maxima at 237.5 nm and fenofibrate at 287.5 nm but the wavelength selected for the proposed methods is 266.0 nm using methanol as solvent. The linearity was observed in concentration range of 5–30μg/ml for metformin and 0.8–4.8μg/ml for fenofibrate. First method is based on solving the simultaneous equation for the two drugs and second method is based on multicomponent analysis. The results of both methods have been statistically validated and found to be satisfactory. The recovery studies confirmed the accuracy of the proposed methods. Top Keywords Metformin hydrochloride, Fenofibrate, Simultaneous equation, Multicomponant. Top | |
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