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Antihistaminic Effect of Sitopaladi Churna Extract Ahirwar Bharti1,*, Ahirwar Dheeraj2, Ram Alpana1 1SLT Institute of Pharmaceutical Sciences, Guru Ghasidas University, Bilaspur (C.G.)-495 009, India 2School of Pharmacy, Chouksey Engineering College, Bilaspur (C.G.) *Corresponding Author E-mail: ah_bharti@yahoo.com
Abstract Anti-inflammatory and mast cell stabilizing activity of sitopaladi churna extract was studied on the egg albumin-induced edema, carrageenin-induced edema in hind paw, cotton pellet implantation, and degranulation of mast cells by compound 48/80. Sitopaladi churna extract exhibited good anti-inflammatory effects in rats, causing a dose-related inhibition of the increase in the paw circumference (acute inflammation) induced by subplantar injection of fresh egg albumin and carrageenin. It also significantly decreased the weight of cotton pellet (chronic inflammation). It also protected mast cell disruption induced by compound 48/80. These findings reveal that antihistaminic and anti-inflammatory activity of sitopaladi churna extract may be due to inhibition of release of inflammatory mediators and mast cell stabilizing potential. Top Keywords Histamine, Carrageenin, Anti-inflammatory. Top | |
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