Synthesis and evaluation of some novel triazolo-thiadizoles derivatives as anti-diabetic activity Dighe Amol S.1,2,*, Sen Ashim K.3,** 1PhD. Scholar, Department of Pharmacy, Sumandeep Vidyapeeth Deemed University, Pipariya, Vadodara, Gujarat State, India 2Assistant Professor, Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni (413736), MH, India 3Professor, Department of Pharmacy, Sumandeep Vidyapeeth Deemed University, Pipariya, Vadodara, Gujarat State, India *Corresponding Author E-mail: amoldighe143@gmail.com
**ashims01@gmail.com
Online Published on 10 October, 2023. Abstract Triazolo-thiodiazole and related fused heterocyclic compounds are of interest as potential bioactive molecules. Triazolo-thiodiazole derivatives have attracted the attention of organic chemists due to their biological and chemotherapeutic significance. Research in the field of anti-mycobacterium, anti-inflammatory and anti-microbial therapies is ongoing and studies are seeking. Therefore, the discovery of new effective anti-mycobacterium, anti-inflammatory and antimicrobial agents is imperative. The literature survey indicates that the fuse ring of triazolo-thiazazole derivatives has proven to be a good bioactive molecule. They showed various biological activities such as antibacterial, antifungal, anti-inflammatory, tubercular, anticancer, anticonvulsant, antioxidant, analgesic. In view of the above facts it was felt that some were interested in triazo- synthesis. All drugs were screened for their anti-diabetic activity with the standard drug Acarbose by an in vitro alpha-amylation method. The compounds C1 and C3 have been shown to have significant anti-diabetic activity. Top Keywords Triazolo-thiodizole, Antibacterial, Anti-diabetic, Antitubercular, Anti-inflammatory. Top |