Accuracy of Nasal House Dust Mite-Specific Immunoglobulin E in Diagnosis of Local Allergic Rhinitis Rosalina Elsa1,**, Pawarti Dwi Reno1, Kristyono Irwan1, Abdullah Baharudin2,* 1Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Mayjen Prof. Dr. Moestopo street No 6-8, Surabaya, Indonesia 2Department of Otorhinolaryngology - Head and Neck Surgery, School of Medical Sciences, Universiti Sains Malaysia, KubangKerian, Kelantan, Malaysia *Corresponding Author E-mail: baharudin@usm.my
**elsarosalina.orlhns@gmail.com
Online Published on 07 February, 2024. Abstract Background Local allergic rhinitis (LAR) is the symptom of allergic rhinitis in which nasal allergen-specific immunoglobulin E(IgE) is detected but has no sensitivity to systemic allergens. The gold standard test is the nasal allergen provocation test (NAPT) which requires a complicated procedure. Specific IgE in nasal mucosa test is the less invasive and easier diagnostic alternative for LAR. Aims This review aimed to determine the validity of the nasal house dust mite - specific IgE test for LAR patients. Study designs A meta-analysis was conducted in chronic rhinitis patients with negative skin prick test (SPT) and serum IgE. Methods The research was using PubMed Central, Cochrane library, SAGE journals, and Science Direct were searched until July 29th, 2022. The validity of the nasal HDM - specific IgE test was compared to NAPT. Results A total of 413 research articles were selected and five articles were included. The QUADAS-2 assessment showed minimum publication bias. The total sample was 236 patients. Pooled sensitivity 90.00%, I2= 28.95% and p=0.01. Pooled specificity 96.00%, I2= 30.28% and p=0.00. The value of the area under the curve in the SROC curve = 0.9710, statistically significant. Conclusion The nasal HDM- specific IgE test is valid for diagnosing patients with LAR. Top Keywords Local allergic rhinitis, Nasal specific immunoglobulin E test, House dust mites, Nasal allergen provocation test, Chronic respiratory diseases. Top |