Assessment of Anti-Microbial Efficacy against Oral Pathogens, Anti-Inflammatory, and Anti-oxidant Activity of Ethanolic and Aqueous Extract of Erythrina variegata (Indian Coral Tree) Leaves – An In-vitro Study Mohapatra Subhashree1,*, Mohandas Rahul2, Doraikannan Sri Sakthi3 1Assistant Professor, Department of Public Health Dentistry, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pimpri, Pune – 411018 2Assistant Professor, Department of Oral Pathology and Microbiology, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pimpri, Pune – 411018 3Reader, Department of Public Health Dentistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai – 600077 *Corresponding Author E-mail: subhashree2005@yahoo.com
Online Published on 07 February, 2024. Abstract Aim The aim of the study was to compare the anti-microbial efficacy against oral pathogens, anti-inflammatory, and antioxidant activity of ethanolic and aqueous extract of Erythrina variegata. Materials and Methods Agar well diffusion method was used to assess the antimicrobial activity of ethanolic and aqueous extract of Erythrina variegata against Enterococcus faecalis and Candida albicans at 25µL, 50µL, and 100µL by measuring the zone of inhibition. Anti-inflammatory activity was assessed using the Bovine Serum Albumin (BSA) assay and anti –oxidant activity was assessed using the DPPH assay. Results Enterococcus faecalis and Candida albicans were found to be less sensitive to both, aqueous and ethanolic extract of Erythrina variegate. The anti-inflammatory activity of ethanolic extract of Erythrina variegata was higher than the aqueous extract at lower concentrations. Anti-oxidant activity of aqueous extract of Erythrina variegata was higher than the ethanolic extract and standard values at all concentrations. Conclusion Findings from this study suggest that both, aqueous and ethanolic extracts of Erythrina variegata leaves have the potential anti-inflammatory and anti-oxidant activity and can be used as an alternative to commercially available drugs. However, further research needs to be done on the antimicrobial activity against oral pathogens of the plant. Top Keywords Anti-microbial efficacy, Oral pathogens, Anti-inflammatory, Anti-oxidant, Erythrina variegate. Top |