Computational Fluid Dynamics as a Simulation tool in the Formulation development of Parenteral and Biphasic Liquid Dosage Forms Bhandarkar Keerthana, Tippavajhala Vamshi Krishna* Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India *Corresponding Author E-mail: vamshi.krishna@manipal.edu, krissrcm@gmail.com
Online Published on 07 February, 2024. Abstract Objectives Parenteral preparations and biphasic liquid dosage forms are commonly available in the market to treat several disease conditions. Formulation and evaluation of these products include critical steps likemixing, filtration, filling, freeze drying and dissolution which areimportantto assure quality of the product. To understand these critical processes, computational fluid dynamics (CFD) can be applied as a simulation tool. Methods The use of CFD in the formulation of parenteral formulations and biphasic liquids is described in this review. Discrete examples of how CFD is used in the formulation and evaluation of parenteral preparations and biphasic liquid dosage forms with an overview of different research works done in every unit operation using CFD will be discussed in this review. Conclusion This review clearly explained the uses and application of CFD as a significant simulation tool in the formulation development of parenteral and biphasic liquid dosage forms. Top Keywords Computational fluid dynamics, Simulation tools, Parenteral formulations, Biphasic liquid dosage forms. Top |