Development a New Diagnostic Based on Autoimmune Markers for Hashimoto Thyroiditis Wuragil Dyah Kinasih1,2, Soeatmadji Djoko Wahono3, Rudijanto Achmad3, Endharti Agustina Tri4, Aulanni’am Aulanni’am5,* 1Doctoral Program in Medical Science, Faculty of Medicine, Universitas Brawijaya 2Department of Veterinary Biochemistry, Faculty of Veterinary Medicine, Universitas Brawijaya 3Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya and Dr Saiful Anwar Hospital, Malang 4Department of Parasitology, Faculty of Medicine, Universitas Brawijaya 5Department of Chemistry, Faculty of Sciences, Universitas Brawijaya *Corresponding Author E-mail: aulani@ub.ac.id
Online Published on 07 February, 2024. Abstract Autoimmune thyroid disease (AITD) especially Hashimoto’s thyroiditis is one of the global health problems that need to handle through proper early detection. Detection through the presence of markers that appear since the pre-disease phase is important as a prevention effort, and as appropriate treatment by clinicians. The aim of this study isto review many approaches to detect Hashimoto’s thyroiditis from available resources/literature. A comprehensive literature review using an available biomedical database, as well as previous studies conducted by the research team. From this works, Hashimoto’s thyroiditis has been detected through a hormone test (thyroxine, T4) and thyroid-stimulating hormone (TSH), cytokine expression because of damage due to inflammation in the thyroid gland, also detect the presence of autoimmune marker of this disease. Many detections assay also have been developed and reported. Hashimoto thyroiditis detection based on the autoimmune marker is the best approach that can be developed and utilized, but it is necessary to know the advantages and disadvantages of these components in various test methods. So that it can provide optimal results. Top Keywords Hashimoto thyroiditis, Detection, Autoimmune markers, Thyroglobulin, Aptamer. Top |