A Review on Thiazole derivatives and their impact as hypoglycemic agents in drug developments Gupta Dheeraj Rajesh1,3, Kumar Pankaj1,3,*, Kumar Abhishek1,3, Kumbar Sachin A1,3, Murugeshwari Vidya1,3, Dixit Seshagiri R2 1Nitte (Deemed to be University), NGSM Institute of Pharmaceutical Sciences (NGSMIPS) 3Department of Pharmaceutical Chemistry, Mangalore, India 2JSS College of Pharmacy, Department of Pharmaceutical Chemistry, Mysore, India *Corresponding Author E-mail: pankajpgr@nitte.edu.in
Online Published on 07 February, 2024. Abstract The impact of thiazole derivatives as a hypoglycemic agent has been noted for many decades. Thiazole is heterocyclic containing sulphur and nitrogen as heteroatom whereas the free pi (π) electrons can move from one bond to another freely to have aromatic properties. Due to these aromatic properties, various reactions are possible with these rings due to the various donor-acceptor position. Thiazole can regulate various physiochemical processes within the body. Due to this, it has been reported for various biological activities such as antimicrobial, antitumor, antidiabetic, antioxidant, anti-inflammatory etc. However, there are various drugs containing thiazole are rosiglitazone, pioglitazone, and troglitazone have shown their effectiveness in controlling elevated blood sugar. In this regard, the present review explains the different thiazole derivatives synthesized and their impact as hypoglycemic agents. Top Keywords Thiazole, Anti-diabetic, α-Amylase, α-Glucosidase. Top |