Aquasomes: A Nanoparticulate approach for the Delivery of Drug Shirole Prathamesh L., Sanap Dhanashree P.*, Jadhav Kisan R. Bharati Vidyapeeth’s College of Pharmacy, Sector-8, CBD Belapur, Navi Mumbai, 400614, Maharashtra, India *Corresponding Author E-mail: dhanashree.sanap@bvcop.in
Online Published on 07 February, 2024. Abstract Aquasomes are one of the most recently developed delivery systems that are found a niche as peptide and protein carriers. Aquasomes are recently developed delivery systems for bioactive molecules like peptides, proteins, hormones, antigens, and genes to specific sites. The delivery system has been successfully utilized for the delivery of insulin, hemoglobin, and enzymes like serratiopeptidase, etc. Aquasomes are nanoparticles made up of calcium phosphate or ceramic diamond coated with a polyhydroxyoligomeric film. They are round nanoparticulate drug delivery systems of around 60-300 nm in size with three layered self-assembled structures. The solid core provides structural stability, while the carbohydrate coating protects against dehydration and stabilizes the biochemically active molecules. Aquasomes can also be referred to as "bodies of water". These water-like characteristics of aquasomes shield and retain delicate biological molecules. Aquasomes are prepared in three steps such as the development of the core, coating of the core, and the loading of the drug. Enzyme activity and sensitivity towards molecular conformation made aquasome a novel carrier for enzymes like DNases and pigment/dyes. The market potential and prospects of aquasomes are given in the article. This review article also includes a brief introduction to aquasomes, method of preparation, advantages, and disadvantages, evaluation parameters, and applications of aquasomes. Top Keywords Aquasomes, Advantages, Nanoparticles, Ceramics, Applications. Top |