Applications of Polymeric Nanoparticle in Nose to Brain Drug Delivery Sunena6,*, Kumar Sumit1, Sulekha2, Tomar Deepali3, Kumar Dinesh4, Kishore Vimal5 6School of Pharmaceutical Sciences, Om Sterling Global University, Hisar - 125001, Haryana, India 1Department of Pharmaceutical Sciences, Central University of Haryana, Jant-Pali, Mahendergarh - 123031, Haryana, India 2Geeta Institute of Pharmacy, Geeta University, Panipat - 132145, Haryana, India 3Lala Birkha Ram College of Pharmacy, Golpura, Panchkula, Haryana, India 4Atam Institute of Pharmacy, Om Sterling Global University 5Dr. A.P.J. Abdul Kalam University, Indore, Madhya Pradesh, India *Corresponding Author E-mail: sunaina.garhwal@gmail.com
Online Published on 07 February, 2024. Abstract The primary goal of developing novel formulations is to effectively deliver the drug the at the target site. A desirable, non-invasive method of enhancing medication penetration or delivering innovative drug or gene carriers into the brain is nose-to-brain administration. The main benefit of intranasal medication administration is that it avoids the blood-brain barrier and targets drug molecules directly to the brain. Due to their difficulty in crossing the blood-brain barrier, big molecular weight and hydrophilic compounds can also be transported to the brain by this drug delivery channel. By speeding the administration of treatments at the target site and preventing systemic adverse effects, intranasal delivery to the brain is helpful in treating many neurological disorders. Potential drug delivery systems, the drug-encapsulated polymeric nanoparticles can convey a sizable amount of medication from the nose to brain. The advantages of polymeric nanoparticles-mediated nose to brain targeting are discussed in this paper. Additionally, it provides an overview of the polymeric nanoparticles studied for the therapy of various brain disorders as well as the process of nanoparticle transport. Top Keywords Intranasal, Blood-brain-barrier, Neurological disorders, Polymeric nanoparticles, Brain targeting, Non-invasive. Top |