Ipomeamarone induced hepatotoxicity in rats: A pathological evaluation Pandey Govind1, Asstt. Professor & Head, Srivastava D.N.1, Ex-Professor & Head of Pharmacology & Toxicology, Shrivastav A.B.*, Prof. of Pathology, Sharma Madhuri*, Lecturer Department of Pharmacology & Toxicology, College of Veterinary Science & Animal Husbandry, Jabalpur (MP) - 482001 1Faculty of Pharmacy, Shri Ram Institute of Technology, Jabalpur *Corresponding author: Faculty of Pharmacy, Shri Ram Institute of Technology, Jabalpur.
Summary An experimental model of hepatotoxicity was produced by ipomeamarone (IPM) in rats. Oral administration of IPM after one month (125, 250 and 500 mg/kg), four months (250 and 500 mg/kg) and eight months (500 and 1000 mg/kg) of isolation damaged the liver within 48 hr. Liver tissues revealed varying degrees of congestion, degeneration and necrosis. The severity and extent of liver damage appeared to be dose dependent. The oral hepatotoxic dose of IPM producing standard liver damage was found to be 250 mg per kg body (after one month of isolation). The hepatotoxicity was characterized by periportal, centrilobular or midzonal necrosis. Top Key words Histopathological changes, Ipomeamarone, Liver damage. Top |