Ameliorative potential of Trianthema portulacastrum L. in cyclophosphamide induced hepatotoxicity and nephrotoxicity in rats Aswathy P. U., Ahmad A. H.*, Pant Disha, Patwal P. C., Verma Manish, Maletha Deeksha Department of Veterinary Pharmacology and Toxicology, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar-263145, Uttarakhand, India *Corresponding author's e-mail: ahahmadpharma@gmail.com
Online published on 28 November, 2023. Abstract The study was undertaken to explore the hepatoprotective and nephroprotective efficacy of hydroethanolic extract of Trianthema portulacastrum (TPHE) in rats administered with cyclophosphamide. Thirty six Sprague Dawley rats were randomly divided into six groups. Group I served as control, group II rats were administered with cyclophosphamide at the dose rate of 100 mg/kg bwt (body weight) p.o. on 9th and 16th day of study; groups III and V were administered hydroethanolic extract of Trianthema portulacastrum (TPHE) only at dose rates 200 mg/kg and 400 mg/kg p.o. respectively, daily and groups IV and VI were given hydroethanolic extract of Trianthema portulacastrum TPHE at 200 mg/ kg and 400 mg/ kg, respectively, for 28 days along with cyclophosphamide at dose rate 100 mg/kg p.o. on 9th and 16th day of the study. TPHE was effective in restoring altered total protein, albumin, globulin, alanine amino transferase, alkaline phosphatase, blood urea nitrogen and creatinine levels. It can be concluded from the study that hydroethanolic extract of Trianthema portulacastrum was effective in ameliorating cyclophosphamide induced hepatic and renal toxicity in rats in a dose-dependent manner. Top Keywords Nephroprotective, Hepatoprotective, Cyclophosphamide, Trianthema. Top |